- The overriding story of Wesker's return and the unveiling of new details about Umbrella link together the chapters as players revisit classic scenarios from previous Resident Evil games.

- Return to classic locations such as the mansion from the original and RE 0, and elements of Raccoon City from RE 3 that lead players to a brand new chapater set in Russia.

- Chris, Jill, Rebecca, Billy and Carlos are all available as playable characters. Other key characters from the Resident Evil series, including Albert Wesker make appearances during the course of the game.

- Using the Wii RemoteTM as a gun, players can experience breathtaking combat against a horde of zombies and various creatures in dynamic first-person perspective.

- Support for Wii ZapperTM provides an even more satisfying, immersive experience.

- Single player or two-player co-op

- 480p and 16:9 Widescreen support

- Switch between pistol, rifle, shotgun, machine gun, knife and grenades to defeat enemies

- Replay the game to achieve higher rankings and access to upgraded weapons. Master the game and achieve an Excellent Ranking to obtain a secret item.
Destroy items to find hidden pick-ups providing key information that reveal vital details about Umbrella

- Certain weapons can destroy environments and items. Shoot objects and watch them splinter, explode and disintegrate. Hidden items may sometimes be found after destroying objects.