Condemned 2: Bloodshot puts players in the identity of Ethan Thomas, a former Serial Crimes Unit investigator. His former partner has gone missing, forcing him to be called back to duty. Ethan's disturbing past has left him a shell of his former self, described by SEGA as a "desperate burnout" who is forced to fight inner demons throughout his investigation.

The sequel will feature a new fighting system that adds defensive and offensive combos along with grapples and holds to the already present arsenal of firearms and blunt tools. New forensic tools are also being promised that allow murders to be solved in a number of different ways